Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

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منابع مشابه

NNMT (nicotinamide N-methyltransferase)

The human NNMT gene is approximately 16,5 kb in length, consists of 3 exons and 2 introns, and is mapped to chromosome 11q23.1. The first intron is 1,240 bp in length, while the second is approximately 14 kb long. The sequence of the 5'-untranslated region (UTR) of the NNMT cDNA is present in exon 1, while the sequence of the cDNA 3'-UTR is present in exon 3 (Aksoy et al., 1995). The initiation...

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Organism aging is a process of time and maturation culminating in senescence and death. The molecular details that define and determine aging have been intensely investigated. It has become appreciated that the process is partly an accumulation of random yet inevitable changes, but it can be strongly affected by genes that alter lifespan. In this review, we consider how NAD(+) metabolism plays ...

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Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD(+)/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory...

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Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration.

NAD+ depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD+ was shown to prevent neuronal degeneration in this process through mechanisms that remained to be determined. The activity of nicotinamide riboside (NR) in neuroprotective models and the recent description of extracellular conversion of NAD+ to NR prompted us t...

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Interferon-gamma elevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells.

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide. NNMT is strongly expressed in tumor cells and an increase in NNMT activity may reduce cellular nicotinamide level and thereby promote cell survival in the cells. However, there has been no report of a relationship between NNMT activity and nicotinamide level in tumor cells. We report herein that human glioma ce...

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ژورنال

عنوان ژورنال: Trends in Endocrinology & Metabolism

سال: 2017

ISSN: 1043-2760

DOI: 10.1016/j.tem.2017.02.004